Phase II study of pentostatin and intermittent high-dose recombinant interferon alfa-2a in advanced mycosis fungoides/Sézary syndrome.
作者： F M Foss , D C Ihde , D L Breneman , R M Phelps , A B Fischmann
DOI: 10.1200/JCO.1992.10.12.1907
关键词:
摘要: PURPOSEThis phase II study was undertaken to assess the efficacy and toxicity of alternating administration pentostatin (deoxycoformycin [DCF]) interferon alfa-2a (IFN) in patients with advanced or refractory mycosis fungoides (MF) Sezary syndrome (SS).PATIENTS AND METHODSForty-one underwent therapy cycles DCF 4 mg/m2 intravenously (IV) days 1 through 3 IFN 10 million U/m2 intramuscularly (IM) day 22, 50 23 26. Twenty-nine had not responded prior chemotherapy total-skin electron-beam irradiation (TSEB), six topical therapies, no previous treatment.RESULTSTwo achieved a complete response (CR) 15 partial (PR), for an overall rate 41% (95% confidence interval, 26% 58%). No responses were observed seven visceral involvement. The median progression-free survival who 13.1 mo...
sci-hub.se 参考文章(38)
Bunn Pa, Lamberg Si, Report of the Committee on Staging and Classification of Cutaneous T-Cell Lymphomas. Cancer treatment reports. ,vol. 63, pp. 725- 728 ,(1979)
Bagshaw Ma, Price Nm, Farber Em, Fuks Z, Hoppe Rt, Cox Rs, Electron-beam therapy for mycosis fungoides: the Stanford University experience. Cancer treatment reports. ,vol. 63, pp. 691- 700 ,(1979)
Gilchrest Ba, Methoxsalen photochemotherapy for mycosis fungoides. Cancer treatment reports. ,vol. 63, pp. 663- ,(1979)
Bizhan Micaily, Eric C. vonderheid, Luther W. Brady, Charles Andrews, Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous t-cell lymphoma International Journal of Radiation Oncology Biology Physics. ,vol. 11, pp. 1111- 1115 ,(1985) , 10.1016/0360-3016(85)90057-4
Stephen Bernard, Parkash Gill, Peter Rosen, Molly Gavigan, Ann Steagall, Elizabeth Ellingham, Tim Morgan, Gracie Janic, Howard Ozer, A phase I trial of α-interferon in combination with pentostatin in hematologic malignancies Medical and Pediatric Oncology. ,vol. 19, pp. 276- 282 ,(1991) , 10.1002/MPO.2950190412
S Broder, R L Edelson, M A Lutzner, D L Nelson, R P MacDermott, M E Durm, C K Goldman, B D Meade, T A Waldmann, The Sézary syndrome: a malignant proliferation of helper T cells. Journal of Clinical Investigation. ,vol. 58, pp. 1297- 1306 ,(1976) , 10.1172/JCI108585
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Frederic J. Kaye, Paul A. Bunn, Seth M. Steinberg, Joyce L. Stocker, Daniel C. Ihde, A.B. Fischmann, Eli J. Glatstein, Geraldine P. Schechter, Ruby M. Phelps, Francine M. Foss, Harry L. Parlette, Michael J. Anderson, Edward A. Sausville, A randomized trial comparing combination electron-beam radiation and chemotherapy with topical therapy in the initial treatment of mycosis fungoides. The New England Journal of Medicine. ,vol. 321, pp. 1784- 1790 ,(1989) , 10.1056/NEJM198912283212603
PETER J. O'DWYER, 2′-Deoxycoformycin (Pentostatin) for Lymphoid Malignancies Annals of Internal Medicine. ,vol. 108, pp. 733- 743 ,(1988) , 10.7326/0003-4819-108-5-733
A.W.F.M. Van Leeuwen, C.J.L.M. Meijer, J.C.H. De Man, T-cell membrane characteristics of "mycosis cells" in the skin and lymph node. Journal of Investigative Dermatology. ,vol. 65, pp. 367- 369 ,(1975) , 10.1111/1523-1747.EP12607618