Estradiol decreases anxiety behavior and enhances inhibitory avoidance and gestational stress produces opposite effects

摘要: Although there is evidence that estradiol has effects in women and animal models to reduce anxiety depressive behavior enhance performance some cognitive tasks, this not seen among all individuals. Given the interaction between hypothalamic–pituitary–adrenal function, we hypothesized an individual's prior exposure stress may mitigate of subsequent estradiol. To address this, rats were exposed gestational stress, or not, determine if during development alters behavioral responses adulthood. If estradiol's on are modulated by experience, then gestationally-stressed administered should have decreased anti-anxiety (open field, elevated plus maze) inhibitory avoidance task. Offspring dams restraint daily days 14–20, no such manipulation, used as adults ei...