Cellular aging towards osteoarthritis

摘要: Osteoarthritis (OA) is a common form of degenerative joint disease. Aging process supposed to be leading predictor for developing OA. In this review, we have discussed the potential roles aging in OA, better understanding which might delay or stop development and progression Different cellular signaling mechanisms are involved that induces age-related changes chondrocytes. These influence expression catabolic factors resulting increased production matrix metalloproteinases cytokines, reduced levels collagen type II aggrecan synthesis, reactive oxygen species (ROS). ROS leads mitochondrial dysfunction chondrocyte death, contributes Antioxidant supplementation probably best way prevent Some therapeutic agents like histone deacetylase inhibitors anti-miR34a been reported effective against However, further research needed demonstrate efficacy these alternative treatment strategies clinical trials using controlled prospective studies.