Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

摘要: The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion over 11,000 tumors from 33 cancer types, we present our current understanding molecular processes governing oncogenesis. We illustrate insights into through synthesis findings TCGA PanCancer project on three facets oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in tumor; (2) influence tumor genome epigenome transcriptome proteome; (3) relationship between microenvironment, including implications for drugs targeting events immunotherapies. These results will anchor future rare common primary relapsed tumors, cancers across ancestry groups guide deployment clinical sequencing.