Chimeric proteins for diagnosis and treatment of diabetes

摘要: Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided immunomodulatory methods for the use such both prevention treatment Type 1 diabetes mellitus. The invention useful in predicting risk onset I diabetes, determining prognosis patients early disease progression, evaluating suitability as recipients transplants pancreatic cells or tissues. administration accordance with results beneficial effects on development severity suffering from predicted to be at developing well outcome tissues patients.