Immunobiological activities of mould products: functional impairment of human monocytes exposed to aflatoxin B1.

作者: V. Cusumano , F. Rossano , R.A. Merendino , A. Arena , G.B. Costa

DOI: 10.1016/0923-2508(96)84713-9

关键词:

摘要: In order to elucidate the effects upon human immune system of aflatoxin B1 produced by food-contaminating mould Aspergillus flavus, phagocytosis, microbicidal activity, superoxide production and intrinsic antiviral activity were studied in monocytes exposed for different times at concentrations ranging from 0.1 1 pg/ml. Phagocytosis significantly impaired (p < 0.05) doses as low However, pretreatment with did not modify or production. These results confirmed data obtained animals fed mycotoxin-contaminated foods. The potential danger health exposure mycotoxins demonstrates necessity careful microbiological control food.

参考文章(16)
Giambrone Jj, Ewert Dl, Wyatt Rd, Eidson Cs, Effect of aflatoxin on the humoral and cell-mediated immune systems of the chicken. American Journal of Veterinary Research. ,vol. 39, pp. 305- ,(1978)
Pier Ac, Mycotoxins and Animal Health Advances in veterinary science and comparative medicine. ,vol. 25, pp. 185- 243 ,(1981)
John L. Richard, John R. Thurston, Billy L. Deyoe, Gordon D. Booth, Effect of Ochratoxin and Aflatoxin on Serum Proteins, Complement Activity, and Antibody Production to Brucella abortus in Guinea Pigs Applied Microbiology. ,vol. 29, pp. 27- 29 ,(1975) , 10.1128/AM.29.1.27-29.1975
C F Chang, P B Hamilton, Impairment of phagocytosis by heterophils from chickens during ochratoxicosis. Applied and Environmental Microbiology. ,vol. 39, pp. 572- 575 ,(1980) , 10.1128/AEM.39.3.572-575.1980
R. Dulbecco, Production of Plaques in Monolayer Tissue Cultures by Single Particles of an Animal Virus Proceedings of the National Academy of Sciences of the United States of America. ,vol. 38, pp. 747- 752 ,(1952) , 10.1073/PNAS.38.8.747
CHAO-FU CHANG, PAT B. HAMILTON, Impairment of Phagocytosis in Chicken Monocytes during Aflatoxicosis Poultry Science. ,vol. 58, pp. 562- 566 ,(1979) , 10.3382/PS.0580562
P. Rafai, S. Tuboly, Effect of T‐2 Toxin on Adrenocortical Function and Immune Response in Growing Pigs Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health. ,vol. 29, pp. 558- 565 ,(2010) , 10.1111/J.1439-0450.1982.TB01255.X
V. Cusumano, G.B. Costa, R. Trifiletti, R.A. Merendino, G. Mancuso, Functional impairment of rat Kupffer cells induced by aflatoxin B1 and its metabolites Fems Immunology and Medical Microbiology. ,vol. 10, pp. 151- 155 ,(1995) , 10.1111/J.1574-695X.1995.TB00025.X
CHAO-FU CHANG, PAT B. HAMILTON, Refractory Phagocytosis by Chicken Thrombocytes during Aflatoxicosis Poultry Science. ,vol. 58, pp. 559- 561 ,(1979) , 10.3382/PS.0580559