Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice

摘要: Nation-wide, opioid misuse among pregnant women has risen 4-fold from 1999 to 2014, with commensurate increase in neonates hospitalized for Neonatal Abstinence Syndrome (NAS). NAS occurs when a fetus exposed opioids utero goes into rapid withdrawal after birth. treatment via continued postnatal exposure been suggested worsen neurodevelopmental outcomes. We developed novel model characterize the impact of and oxycodone (Oxy) on early behavior development. Via subcutaneous pump implanted before breeding, C57BL/6J dams were infused at 10 mg/kg/day conception through pup-weaning. At birth, oxy-exposed pups either cross-fostered (paired non-oxy dams) abstinence (short-oxy) or reared by their biological still receiving Oxy (long-oxy). Offspring vehicle-exposed served as (short-veh) biologically-reared (long-veh) controls. Short-oxy resulted sex-dependent weight reductions altered spectrotemporal features isolation-induced ultrasonic vocalization (USV). Meanwhile, long-oxy exhibited reduced sex-differential delays righting reflex. Specifically, female offspring increased latency Long-oxy also showed decreases number USV calls, changes features. Overall, ontogenetic was associated impaired attainment gross sensorimotor milestones, well alterations communication affective behaviors, indicating need therapeutic interventions. The here will enable studies physiology opioid-mediated mechanisms underlying these deficits.