Application of Population Pharmacokinetic-Pharmacodynamic Approaches in the Design of Translational Strategies for Development of Antibody-Based Therapeutics

摘要: Population-based pharmacokinetic-pharmacodynamic (PK-PD) approaches have been successfully applied in various stages of drug development over the last few decades. The antibody-based therapeutics has benefited substantially from utilization population approaches. Moreover, almost all FDA-approved monoclonal antibody evaluated using In this chapter, application PK-PD methods will be reviewed context translational strategies employed during therapeutics.