A comparison of myocardial perfusion and rejection in cardiac transplant patients.

摘要: Although histological evaluation of the cardiac tissue is current gold standard for rejection, we hypothesized that perfusion MRI a safe non-invasive method correlates blood flow changes with biopsy proven rejection in transplant patient. In retrospective study from 1984–2001, 83 patients underwent 135 MR Gd-DTPA imaging studies. 8 (9%), biopsies graded 2 or higher (by ISHLT criteria) provided evidence rejection. Patients were age and sex matched to 11 non-rejected controls analysis. Time–signal intensity curves generated mid-ventricle LV short axis slice during rest adenosine stress allowed determination myocardial (MBF, ml/min/gm). ROC curve analysis by SPSS estimation sensitivity specificity. At rest, there was no difference MBF between prior vs. those without (1.18 ± 0.26 1.16 0.29). decrease episodes (3.27 0.74) compared (3.60 ± 0.72), P = 0.067). The area under 0.82, specificity 75% 81%, respectively. This suggests can be used assessing patient related microvascular changes. high recorded illustrates potential utility this diagnostic test future