Relationship between sex hormone-binding globulin levels and features of the metabolic syndrome.

摘要: Abstract Previous studies have demonstrated that reduced plasma levels of sex hormone-binding globulin (SHBG) are related to alterations in several features the metabolic syndrome both men and women. We investigated whether SHBG level was a global predictor sample 203 men, 173 premenopausal, 46 postmenopausal women for whom we also obtained detailed assessment profile, including body composition (hydrostatic weighing), abdominal adipose tissue areas (computed tomography), lipid-lipoprotein levels, glucose homeostasis (oral challenge). Low were associated with increased total adiposity as well pre- an altered especially premenopausal Subjects subdivided according presence 0, 1 2, or 3 more syndrome. Twenty-five percent characterized by more, whereas most (61.3%) had healthy profile (0 features) 6.9% features. Most (54.3%) 2 components syndrome, 13.0% components. The proportion subjects (3 more) lower values upper tertile compared (17.7% v 28.4% 1.7% 14.0%, respectively). Logistic regression analyses indicated significant reduction probability being (odds ratios 0.35, P = .02 .11, .05 women, reference). logistic not These results suggest may represent