Characterization of a Transplantable Adenocarcinoma of the Mouse Colon Producing Cachexia in Recipient Animals

摘要: MAC16 is a chemically induced, transplantable adenocarcinoma of the colon passaged in inbred NMRI mice. At small tumor burdens (less than 1% host weight), weight loss was observed without reduction food intake. As mass increased, also increased and reached 33% body females 20% males when compared with age-matched controls. The directly proportional to size reversible excised. There preferential fat tumor-bearing animals an increase plasma level free fatty acids, although there minimal elevation ketone bodies. Tumor growth accompanied by progressive hypoglycemia insulin levels. decrease may have contributed catabolic effects growth.