The impact of long-term changes in metabolic status on cardiovascular biomarkers and microvascular endothelial function in middle-aged men: a 25-year prospective study.

摘要: The aim of this analysis was to examine long-term effects changes in metabolic status on microvascular endothelial function and cardiovascular diseases (CVD) biomarkers among physically active middle-aged men. Metabolically healthy men (n = 101, mean age 59.7 years), free symptoms treatment, have been prospectively observed for their lifestyle CVD risk factors (observation period 24.7 years). At the latest follow-up (2011/2012) a set measured using enzyme-linked immunosorbent assay. Microvascular evaluated by means reactive hyperemia index (RHI) Endo-PAT2000 system. participants were divided into metabolically (0–1 parameters) unhealthy (≥2 groups. Metabolic syndrome defined according NCEP ATP III definition. Traditional significantly associated with hsCRP, ox-LDL, Il-6, leptin adiponectin/leptin ratio. Reactive negatively related body mass (p < 0.01), waist circumference (p < 0.05), triglycerides TG/HDL ratio uric acid sICAM-1 (p < 0.05) Il-6 positively HDL-C (p < 0.01) leisure-time physical activity (p < 0.01). Men who maintained (n = 47) through observation had lower hsCRP higher RHI prevalence dysfunction as compared group (n = 54). Regular level individuals during whole observation. Even subtle profile influence inflammatory function. Leptin, are significant predictors profile. Interleukine-6 may be used indicators early asymptomatic High is an important contributor middle adulthood.