Cryptococcus neoformans : a Sugar-Coated Killer

摘要: The main principles for the genetic pathophysiology of cryptococcosis will probably be consistent among all three varieties. In this chapter author considers yeasts to different varieties or serotypes. Seven major areas are examined support potential molecular insights into pathogenic yeast which allow one identify drug targets, define resistance mechanisms, and/or prepare mutants fungal products protective vaccines. Initial biology studies focused on distinguishing strain differences with use karyotypes, repetitive elements, and eventually randomly amplified polymorphic DNAs, amplification fragment length polymorphisms, PCR fingerprinting genotyping. Cryptococcus neoformans has several well-characterized virulence phenotypes have been approached in their understanding by both tools. Experimental animal models tended associated large inocula some type induced immunosuppression. summary, encapsulated C. developed a human pathogen over last two decades. It causes serious infection we can treat, but it is still substantial morbidity mortality correctly called sugar-coated killer neoformans, keys place unlock mysteries what means pathogen. This basidiomycete become model study pathogenesis, although unique features, many paradigms discovered its used understand other invasive mycoses.