Characterization of maghemite (γ-Fe2O3)-loaded poly-l-lactic acid/thermoplastic polyurethane electrospun mats for soft tissue engineering
作者： Ehsan Fallahiarezoudar , Mohaddeseh Ahmadipourroudposht , Ani Idris , Noordin Mohd Yusof , Mohsen Marvibaigi
DOI: 10.1007/S10853-016-0087-1
关键词:
摘要: This study proposed a new mixture of three different biocompatible and biodegradable materials for soft tissue which needs elasticity stretchability as well stiffness. Five ratios poly-l-lactic acid (PLLA)/thermoplastic polyurethane (TPU) blend containing 1 % (w/v) maghemite (γ-Fe2O3) nanoparticles were electrospun characterized in terms morphology, degradation rate, biological compatibility, mechanical properties tunable properties. Neat PLLA/TPU samples used effect verification. The existence components the mats was confirmed by Fourier transform infrared spectroscopy energy-dispersive X-ray spectroscopy. Scanning electron microscopy images illustrated well-fabricated nanofibers with smaller diameter distribution PLLA. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay using human skin fibroblast cell indicates desired proliferation migrant over samples. Blood biocompatibility results clotting time, fibrin formation, hemolysis almost normal range. Samples’ rate investigated 24 weeks where PLLA shows 47.15 mass change, while 6.7 TPU changed. High tensile strength an extremely low elongation at break determined from stress–strain curve PLLA, exhibits high elasticity. 50:50 ratio maghemite-loaded scaffold presents overall satisfaction.
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