摘要: Elimination of cells through apoptosis is crucial for tissue homeostasis. The process cell removal regulated by the expression recognition signals on dying and corresponding phagocytosis receptors engulfing cell; in addition, chemotactic factors emitted apoptotic corpses serve to attract macrophages site attrition. Cell clearance thus an active, programmed as such thought play important role resolution inflammation prevention autoimmune diseases. Moreover, recent studies suggest that engulfment remnants may result lateral transfer genetic information within a tumour population, contribute cancer progression. In several have established link between malignant transformation autophagy, alternative form death. Further elucidation mechanism disposal (occurring either or autophagy/self-digestion) expected aid our understanding development unveil novel targets therapeutic intervention.
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