Exploiting scavenger receptors in cancer immunotherapy: Lessons from CD5 and SR‐B1

摘要: Scavenger receptors (SRs) are structurally heterogeneous cell surface characterized by their capacity to remove extraneous or modified self-macromolecules from circulation, thus avoiding the accumulation of noxious agents in extracellular space. This scavenging activity makes SRs important molecules for host defense and homeostasis. In turn, keep activation steady state immune response check, participate as co-receptors priming effector responses when macromolecules associated with a threat that might compromise Therefore, built up sophisticated sensor mechanisms controlling system, which may be exploited develop novel drugs cancer immunotherapy. this review, we focus on regulation anti-tumor two paradigmatic SRs: lymphocyte receptor CD5 more broadly distributed scavenger class B type 1 (SR-B1). Cancer immunity can boosted blockade working checkpoint inhibitors (CD5) and/or proper engagement innate danger Thus, these illustrate both complexity targeting immunotherapy also opportunities offered such an approach. This article is protected copyright. All rights reserved