Genetic variants in noncoding PIWI‐interacting RNA and colorectal cancer risk
作者： Haiyan Chu , Liping Xia , Xiaonan Qiu , Dongying Gu , Linjun Zhu
DOI: 10.1002/CNCR.29314
关键词:
摘要: BACKGROUND PIWI-interacting RNAs (piRNAs), which are a novel type of identified small noncoding RNA (ncRNA), play crucial role in germline development and carcinogenesis. METHODS By systematically screening all known piRNAs, the authors 7 common single nucleotide polymorphisms (SNPs) 9 piRNAs. Associations between these selected SNPs risk colorectal cancer (CRC) were detected case-control study. A quantitative real-time polymerase chain reaction assay was used to evaluate messenger (mRNA) expression levels piR-015551 long ncRNA (lncRNA) LNC00964-3 88 pairs tissue samples. RESULTS The revealed that reference SNP rs11776042 significantly associated with decreased CRC an additive model (P = .020). However, this protective effect not significant after correction for multiple comparisons (test false discovery rate; P = .140). Furthermore, observed mRNA (an lncRNA included sequence but piR-015551) lower tissues than corresponding normal (P = 1.5 × 10−5 LNC00964-3; P = .899 piR-015551). Correlation analysis positively correlated (CRC tissues: r = 0.574, P = 5.13 10−9; r = 0.601, P = 5.76 10−10). Moreover, or (all P > .05). CONCLUSIONS The current findings reveal possibility may be generated from LNC00964-3, involved CRC. Cancer 2015;121:2044–2052. © 2015 American Society.
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