Spectroscopic and kinetic studies on the interaction of ketoconazole and povidone drugs with DDQ
作者： M. Pandeeswaran , K.P. Elango
DOI: 10.1016/J.SAA.2007.06.007
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摘要: Abstract The kinetics and mechanism of the interaction between 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) ketoconazole povidone drugs has been investigated spectroscopically. In presence large excess donor, 1:1 CT complex is transformed into a final product, which isolated characterized by FT-IR GC–MS techniques. rate formation product measured as function time in different solvents at three temperatures. thermodynamic parameters, viz. activation energy, enthalpy, entropy free energy were computed from temperature dependence constants. Based on spectro-kinetic results plausible for its transformation presented discussed.
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