Effect of magnesium ion incorporation on the thermal stability, dissolution behavior and bioactivity in Bioglass-derived glasses

摘要: Abstract There is a strong discrepancy in the literature regarding effect of magnesium on bioactive glasses. Hence present study focused physical and chemical behavior “golden standard” 45S5 glass magnesium-containing glasses developed here to evaluate their reactivity vitro bioactivity. The aim this was analyze influence CaO replacement by MgO, especially its rate formation apatite-like layer at surface, reaction kinetics between simulated body fluid (SBF-K9) stability against devitrification during heating. Five melt-derived system 24.3Na 2 O–26.9(xCaO − (1 − x)MgO)–46.3SiO –2.5P O 5 (x = 1; 0.875; 0.75; 0.625 0.5) were synthesized with progressively replaced MgO. Their thermal heating characterized DSC analysis. degradation ability form an evaluated through tests immersion SBF-K9; FTIR, ion selective electrode analysis solid state nuclear magnetic resonance (NMR) spectroscopy. Our results indicate that plays important role family, defined as difference transition temperature T g crystallization x . lower observed MgO-rich insignificantly changed solubilities, well 29 Si NMR suggest MgO does not act network intermediate or former oxide, but modifier, we expected. Dissolution kinetics, 31 P 1 H MAS-NMR consistently partial bioglass which initial amorphous calcium phosphate (ACP) precipitated when exposed SBF. In contrast it greatly reduces conversion precursor phase crystalline hydroxycarbonate apatite (HCA)-layer.