Unbalanced thermoregulation in experimental autoimmune encephalitis induced in Lewis rats.

摘要: Abstract Thermoregulation in patients suffering from multiple sclerosis (MS) is impaired and may result either increases or decreases body temperature. We have found that rat experimental autoimmune encephalitis (EAE), being a model of MS, associated with temperature disturbances as well. The purpose the current study was to examine whether altered EAE-induced rats due deficit thermoregulation controlled change its set point. Subcutaneous injection encephalitogenic emulsion into both pads hind feet Lewis provoked EAE symptoms. Body (Tb) 6 measured using biotelemetry system, ambient (Ta) preferred by another group analyzed thermal gradient system. Symptoms started 11 days postinjection progressed quickly, culminating complete paralysis placed gradient, which behavioural fever (accordingly, selected Ta raised much 32.8 ± 0.5 °C vs 27.2 ± 0.6 °C control rats). On other hand, rats, at constant 24 °C, were able generate (Tb 37.8 ± 0.1 °C) start illness then compromised (most likely an impairment thermogenesis), which, surprisingly, resulted recovery. conclude onset supporting leads aggravation neurotoxicity.