The degradation of phospholipids, formation of metabolites of arachidonic acid, and demyelination following experimental spinal cord injury.
作者： LLOYD A. HORROCKS , PAUL DEMEDIUK , ROYAL D. SAUNDERS , LAURA DUGAN , NANCY R. CLENDENON
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摘要: ABSTRACT Spinal cord injury has been studied using a cat compression model. Very early changes in lipid metabolism were found that compromise the integrity of plasma membrane and decrease activities ATPases. Up to 18% ethanolamine plasmalogens are lost, with very marked elevations free fatty acids, arachidonic acid, diacylglycerols, prostaglandins, thromboxanes, leukotrienes. These result edema, inflammation, necrosis oligodendroglia, demyelination, paralysis.
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