Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene.
作者： C. E. Gauwerky , F. G. Haluska , Y. Tsujimoto , P. C. Nowell , C. M. Croce
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摘要: Abstract We have analyzed the molecular genetics of breakpoints involved in t(8;14) and t(14;18) translocations an acute pre-B-cell leukemia from a patient with history follicular lymphoma. In this patient's leukemic cells, breakpoint translocation occurred major breakpoint-cluster region BCL2 gene became linked to JH4 joining-region segment immunoglobulin heavy-chain locus on 14q+ chromosome as previously observed An N heptamer nonamer signal sequences indicated that mistake VH-DH-JH joining (where VH DH are variable diversity segments). translocation, was located immediately 5' first exon MYC protooncogene, which juxtaposed C gamma 2 constant second chromosome. The finding repeated typical switch regions suggested during isotype switching, resulting progression both translocations. terminal deoxynucleotidyltransferase-positive phenotype cells further suggests derived pre-B cell carrying original polymerase chain reaction method then used identify cancer bone marrow patient.
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