Subcutaneous Perfusion and Oxygen During Acute Severe Isovolemic Hemodilution in Healthy Volunteers

摘要: Hypothesis Acute severe isovolemic anemia (to a hemoglobin [Hb] concentration of 50 g/L) does not decrease subcutaneous wound tissue oxygen tension (PsqO 2 ). Setting University hospital operating room and inpatient general clinical research center ward. Subjects Twenty-five healthy, paid volunteers. Methods Subcutaneous temperature (Tsq) were measured continuously during hemodilution to an Hb level g/L. In 14 volunteers (initially well-perfused), "normal" perfusion (Tsq >34.4°C) was achieved by hydration systemic warming prior starting hemodilution, while in 11 (perfusion controlled [PNC]), no attempt made control hemodilution. Main Outcome Measures Measurements PsqO , Tsq, relative blood flow (flow index). Results While index significantly lower PNC vs well-perfused subjects at baseline, there significant difference between them the g/L (nadir). PO did either group. Arterial different groups, change over time; Tsq increased from baseline nadir both groups. Conclusions The maintained levels healthy volunteers, whether they initially or mildly underperfused peripherally. Given increase index, this resulted compensatory sufficient maintain delivery. Wound healing depends large extent on delivery, these data suggest that even itself would be impair healing. Thus, transfusion autologous packed red cells solely improve surgical patients with other indication for is supported results.