AUTOSYNCHRONIZATION OF RAT LIVER CELLS WITH ENDOGENOUS CORTICOSTERONE AFTER PARTIAL HEPATECTOMY

摘要: After adrenalectomy in adult male rats 3H-TdR incorporation into the liver parenchymal cells is increased 4–8 times and mitotic index rises from 0–31 % to 1–3%; this inhibited by corticosterone. hepatectomy serum corticosterone level increases 18 μg/100 ml 57 ml. The binding capacity of declines 2–06 0–17. activity tyrosine transaminase doubles, whereas decreased a factor 5–7. Thereafter again reaches, 24 hr after operation, value 3–82. content return normal. incorporation, however, 7-7 initial value. We concluded that first few hours partial blocks G1 an accumulation occurs at cell cycle phase. Folio wing proteins little later enter S-phase synchronously.