Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning.

摘要: Abstract Acutely administered antidepressants possess a multiplicity of pharmacological actions. However, the fact that agents possessing similar actions are devoid antidepressant activity, together with lack correlation between doses required for acute effects and clinical efficacy, suggest mechanism(s) action cannot be directly attributed to properties drugs. The lag phase in onset effectiveness emphasizes importance adaptive changes following chronic administration. A rapidly accelerating trend attempting delineate precise molecular mechanisms is shift emphasis therapies from alterations uptake, storage, synthesis release neurotransmitters receptor functioning. These adaptations occur both pre- postsynaptically. Examples former alpha 2 DA presynaptic receptors, being down-regulated by certain forms therapy. NE-coupled adenylate cyclase system rat brain slices tricyclics, atypical antidepressants, MAO inhibitors ECT system. Electrophysiological behavioral studies point up-regulation central 1 5-HT functioning long-term In contrast beta-adrenoceptor, these findings correlated data radioligand binding studies. general -adrenoceptor remains unaltered. This also true whereas cortical increased decreased depending on type therapy investigated. relationship efficacy man not clear since there generally good models studying human review current animal would tend disfavour view all common mechanism action. Perhaps multiple intervention sites exist. introduction evaluation specificity will undoubtedly aid psychotherapeutic research. knowledge peptides ‘classical’ can co-exist same neurone generate significance co-transmitter function therapies.