Cardiac rupture, mortality and the timing of thrombolytic therapy: A meta-analysis
作者： Michael B. Honan , Frank E. Harrell , Keith A. Reimer , Robert M. Califf , Daniel B. Mark
DOI: 10.1016/0735-1097(90)90586-E
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摘要: Abstract This study examined the relation between risk of cardiac rupture and timing thrombolyiic therapy for acute myocardial infarction. To test hypothesis that rapture is prevented by early thrombolytic but promoted late treatment, randomized controlled trials or thrombolytk agents infarction were pooled. A logistic regression model including 58 cases among 1,638 patients from four showed odds ratio (treated/control) was directly correlated with time to treatment (p = 0.01); at 7 h, 0.4 (95% confidence limits 0.17 0.93); 11 it 0.93 (0.53 1.60) 17 3.21 (1.10 10.1). Analysis data Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI) trial independently confirmed 0.03). 4,692 deaths in 44346 demonstrated death also 0.006); 3 0.72 (0.67 0.77); 14 0.88 (0.77 1.06) 21 1 (0.82 1.37). Thrombolytic after improves survival decreases rupture. Late administration appears improve may increase
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