Seizures during clozapine therapy.

摘要: Seizures are important adverse effect of clozapine therapy; a cumulative 10% risk tonic-clonic seizure is estimated after 3.8 years treatment. Although the seizures may be increased by rapid upward titration and higher doses, recent data do not clearly confirm dose-dependent effect. The vast majority clozapine-related tonic-clonic, although myoclonic also occur. role EEG in predicting occurrence clozapine-induced remains uncertain. In patients with seizures, either reducing dose or adding an antiepileptic medication usually allows continuation therapy