Targeted laser ablation of the zebrafish larval heart induces models of heart block, valvular regurgitation, and outflow tract obstruction.
作者： Gianfranco Matrone , Sana Maqsood , Jonathan Taylor , John J. Mullins , Carl S. Tucker
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摘要: Abstract Mammalian models of cardiac disease have provided unique and important insights into human but become increasingly challenging to produce. The zebrafish could provide inexpensive high-throughput injury repair. We used a highly targeted laser, synchronized fire at specific phases the cycle, induce regional ventricle, atrioventricular (AV) cushion, bulbus arteriosus (BA). assessed impact laser on hearts early larvae 72 h postfertilization, different regions, recording effects ejection fraction (EF), heart rate (HR), blood flow 2 24 h postinjury (hpi). Laser apex, midzone, outflow regions ventricle resulted in reductions EF hpi with full recovery function by 24 hpi. close AV was more likely cause bradycardia atrial–ventricular dysfunction, suggestive an electrical conducti...
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