Effects of motivational interviewing-based adherence therapy for schizophrenia spectrum disorders : a randomized controlled trial

摘要: Non-adherence to antipsychotic medication is commonly found in schizophrenia and other psychotic disorders, thus forming a major obstacle long-term maintenance treatment contributing high relapse rates. With limited evidence on the success of interventions enhancing adherence, this controlled trial was designed test evaluate effectiveness an adherence therapy (AT) for outpatients with spectrum based motivational interviewing approach over six-month follow-up period. A single-blind, randomized repeated-measures, two parallel groups design conducted random sample 114 participants disorders one community psychiatric nursing service. After pre-test, were randomly assigned either eight-session course AT plus usual care or (n = 57 per group). The main outcomes, including symptom severity, insight into treatment, hospitalization rate, functioning, measured at baseline immediately six months post-intervention. total 110 completed attrition rate 3.5 %. Results repeated-measures analysis variance followed by Helmert’s contrasts indicated that reported significantly greater improvements their illness and/or psychosocial number re-hospitalizations, (F = 5.01 7.45, P = 0.007 0.030) follow-up, when compared care. Motivational interviewing-based people can be effective reduce severity improve medium term (six months) period follow-up. Further study effects terms diverse sociodemographic characteristics, longer (for example, 12 months) recommended. registered Clinicaltrials.gov (identifier: NCT01780116 ) 6 July 2014.