Cell cycle perspectives on breast cancer cell behaviour

摘要: Uncontrolled proliferation and the capacity to infiltrate surrounding tissues are two important characteristics of aggressive tumour cells. Previous observations in both colorectal cancer basal cell carcinoma indicated that infiltrative behaviour might be counteracted by a high proliferative activity, suggesting coordination these activities at cellular level. Here we studied potential relation between activity migratory breast cancer, focusing on cycle regulatory proteins cyclin E D1. By expressing line obtained experimental results indicating increased obstructed invasive capacity. When validating large set primary cancers, observed increasing levels correlated with less growth appearance – finding our results. Several studies have proposed is strongly associated poorer disease outcome cancer. Therefore, continued investigate prognostic relevance inverse growth. We revealed distinct subgroup infiltrative, cancers relatively favourable prognosis. This was an exception compared majority tumours where indeed outcome. also tried delineate detail how capacities cells related activities. Synchronised G0/early G1 displayed late G1/S-phase as well unsynchronised, actively cycling Further, silencing D1 lines novel CDK- independent function restraining role seemed influence ER positive tumours, were general smaller size and, further, exhibited somewhat pattern. In addition, more (Less)