Cardiac troponin T release in acute myocardial infarction is associated with scintigraphic estimates of myocardial scar.

摘要: BACKGROUND This study compared clinical-chemical estimates of infarct size with scintigraphic myocardial scar in patients first-time acute infarction (AMI). METHODS Levels the cardiac isoform contractile protein troponin T (TnT), creatine kinase (CK), and isoenzyme MB CK (CK MB) were tested serially drawn blood samples from 21 (two females 19 males; median age, 55 years). Of these patients, five had anterior- 16 inferior-wall AMI; all received intravenous thrombolytic therapy. Single-photon emission computed tomography (SPECT) technetium-99m-isonitrile (Tc-sestamibi) was performed at rest after onset AMI (median time, 5 weeks). Scintigraphic defects calculated using "bull's-eye" polar coordinate maps. All an uncomplicated course between discharge scintigraphy. RESULTS defect sizes ranged 3.2% to 47.8% left ventricle (median, 27.3%). Cardiac TnT release correlated closely each other scar. Significant correlates found peak values (r = 0.87, P 0.0001), peaks Tc-sestamibi 0.73, 0.0014), 0.0011). CONCLUSIONS Because animal studies have already shown a very close correlation histologic SPECT size, our results indicate that is useful marker assess noninvasively man.