Methylglyoxal-derived advanced glycation endproducts in multiple sclerosis
作者： Suzan Wetzels , Kristiaan Wouters , Casper Schalkwijk , Tim Vanmierlo , Jerome Hendriks
DOI: 10.3390/IJMS18020421
关键词:
摘要: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The activation inflammatory cells crucial for development MS and shown to induce intracellular glycolytic metabolism in pro-inflammatory microglia macrophages, as well CNS-resident astrocytes. Advanced glycation endproducts (AGEs) are stable formed by reaction dicarbonyl compounds methylglyoxal (MGO) glyoxal (GO) with amino acids proteins, during glycolysis. This suggests that, MS, MGO-derived AGEs glycolysis-driven cells. MGO can further activate binding receptor advanced (RAGE). Recent studies have revealed that increased plasma brain patients. Therefore, might contribute status MS. Moreover, main detoxification compounds, glyoxalase system, seems be affected patients, which may high AGE levels. Altogether, evidence emerging contributing role pathology In this review, we provide an overview current knowledge on involvement
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