Inhibition by picotamide of thromboxane production in vitro and ex vivo.
作者： F. Violi , A. Ghiselli , L. Iuliano , D. Pratic� , C. Alessandri
DOI: 10.1007/BF00542494
关键词:
摘要: The effect of picotamide on platelet function has been studied in vitro and ex vivo. Picotamide at micromolar concentrations inhibited aggregation induced by ADP, arachidonic acid collagen, it also the production thromboxane A2 (TxA2). Unlike aspirin, did not affect synthesis prostacyclin blood vessels. In eight healthy subjects who took 1200 mg/d TxA2 were inhibited. appears to be an antiplatelet drug that reduces without affecting cyclo-oxygenase activity.
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