Bacterial meningitis: insights into pathogenesis and evaluation of new treatment options: a perspective from experimental studies

摘要: Bacterial meningitis is associated with high mortality and morbidity rates. components induce an overshooting inflammatory reaction, eventually leading to brain damage. Pathological correlates of neurofunctional deficits include cortical necrosis, damage the inner ear hippocampal apoptosis. The dentate gyrus important for memory acquisition harbors a neuronal stem cell niche, thus being potentially well equipped regeneration. Adjuvant therapies aimed at decreasing example, dexamethasone, those protecting from injury have been evaluated in animal models disease. They nonbacteriolytic antibiotics (e.g., daptomycin), metalloproteinase inhibitors modulators immunological response, granulocyte colony-stimulating factor. Increasing research interest has recently focused on interventions supporting regenerative processes.