Transient receptor potential vanilloid type 1 and pain development
作者： Enza Palazzo , Livio Luongo , Vito de Novellis , Francesco Rossi , Ida Marabese
DOI: 10.1016/J.COPH.2011.10.022
关键词:
摘要: Transient receptor potential vanilloid type 1 (TRPV1), a ligand-gated cation channel, is polymodal nocitransducer widely expressed within pain transmitting/modulating areas of the peripheral and central nervous system. TRPV1 both activated sensitized by inflammatory endogenous mediators during conditions appears to be up regulated in neuropathic conditions. Owing its role as integrator, widespread expression neuraxis involvement development offers an exciting opportunity for therapeutic interventions management. In particular, supraspinal antinociceptive descending pathway, which includes periaqueductal grey (PAG) rostral ventromedial medulla (RVM), represents switch extinguishing pathological
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sci-hub.se 参考文章(136)
Jihong Xing, Jianhua Li, TRPV1 Receptor Mediates Glutamatergic Synaptic Input to Dorsolateral Periaqueductal Gray (dl-PAG) Neurons Journal of Neurophysiology. ,vol. 97, pp. 503- 511 ,(2007) , 10.1152/JN.01023.2006
Sabatino Maione, Tiziana Bisogno, Vito de Novellis, Enza Palazzo, Luigia Cristino, Marta Valenti, Stefania Petrosino, Vittorio Guglielmotti, Francesco Rossi, Vincenzo Di Marzo, Elevation of Endocannabinoid Levels in the Ventrolateral Periaqueductal Grey through Inhibition of Fatty Acid Amide Hydrolase Affects Descending Nociceptive Pathways via Both Cannabinoid Receptor Type 1 and Transient Receptor Potential Vanilloid Type-1 Receptors Journal of Pharmacology and Experimental Therapeutics. ,vol. 316, pp. 969- 982 ,(2006) , 10.1124/JPET.105.093286
Arpad Szallasi, Peter M. Blumberg, Vanilloid (Capsaicin) Receptors and Mechanisms Pharmacological Reviews. ,vol. 51, pp. 159- 212 ,(1999)
John B. Davis, Julie Gray, Martin J. Gunthorpe, Jonathan P. Hatcher, Phil T. Davey, Philip Overend, Mark H. Harries, Judi Latcham, Colin Clapham, Kirsty Atkinson, Stephen A. Hughes, Kim Rance, Evelyn Grau, Alex J. Harper, Perdita L. Pugh, Derek C. Rogers, Sharon Bingham, Andrew Randall, Steven A. Sheardown, Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia Nature. ,vol. 405, pp. 183- 187 ,(2000) , 10.1038/35012076
Craig Montell, Lutz Birnbaumer, Veit Flockerzi, René J. Bindels, Elspeth A. Bruford, Michael J. Caterina, David E. Clapham, Christian Harteneck, Stefan Heller, David Julius, Itaru Kojima, Yasuo Mori, Reinhold Penner, Dirk Prawitt, Andrew M. Scharenberg, Günter Schultz, Nobuyoshi Shimizu, Michael X. Zhu, A Unified Nomenclature for the Superfamily of TRP Cation Channels Molecular Cell. ,vol. 9, pp. 229- 231 ,(2002) , 10.1016/S1097-2765(02)00448-3
Sujung Ryu, Beiying Liu, Feng Qin, Low pH Potentiates Both Capsaicin Binding and Channel Gating of VR1 Receptors Journal of General Physiology. ,vol. 122, pp. 45- 61 ,(2003) , 10.1085/JGP.200308847
Zhi-Ye Zhuang, Haoxing Xu, David E Clapham, Ru-Rong Ji, None, Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory Neurons and Mediates Inflammatory Heat Hyperalgesia through TRPV1 Sensitization The Journal of Neuroscience. ,vol. 24, pp. 8300- 8309 ,(2004) , 10.1523/JNEUROSCI.2893-04.2004
Andres Nieto-Posadas, Andres Jara-Oseguera, Tamara Rosenbaum, TRP Channel Gating Physiology Current Topics in Medicinal Chemistry. ,vol. 11, pp. 2131- 2150 ,(2011) , 10.2174/156802611796904870
Gregory J. Michael, John V. Priestley, Differential Expression of the mRNA for the Vanilloid Receptor Subtype 1 in Cells of the Adult Rat Dorsal Root and Nodose Ganglia and Its Downregulation by Axotomy The Journal of Neuroscience. ,vol. 19, pp. 1844- 1854 ,(1999) , 10.1523/JNEUROSCI.19-05-01844.1999
Yi Dai, Tomoko Moriyama, Tomohiro Higashi, Kazuya Togashi, Kimiko Kobayashi, Hiroki Yamanaka, Makoto Tominaga, Koichi Noguchi, Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. The Journal of Neuroscience. ,vol. 24, pp. 4293- 4299 ,(2004) , 10.1523/JNEUROSCI.0454-04.2004