MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer
作者： Nicola Valeri , Chiara Braconi , Pierluigi Gasparini , Claudio Murgia , Andrea Lampis
DOI: 10.1016/J.CCR.2014.03.006
关键词:
摘要: MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little known as to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b overexpression triggered mice and humans by APC loss, PTEN/PI3K pathway deregulation, SRC promotes transformation progression. upregulation common sporadic inflammatory bowel disease-associated CRCs correlates with stage poor clinical outcome. Inhibition of CRC mouse models reduces growth controlling genes involved proliferation, invasion, apoptosis. identify key downsteam effector oncogenic pathways potential target for treatment.
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