Inactivated and Adjuvanted Influenza Vaccines

摘要: Inactivated influenza vaccines are produced every year to fight against the seasonal epidemics of influenza. Despite nonoptimal coverage, even in subjects at risk like elderly, pregnant women, etc., these significantly reduce burden mortality and morbidity linked infection. Importantly, have also contributed impact last pandemics. Nevertheless, performance can be improved mainly those age groups, children which their efficacy is suboptimal. The use adjuvants has proven effective this scope. Oil-in-water MF59 AS03 been licensed widely used, shown efficacious preventing infection pandemic. MF59-adjuvanted inactivated vaccine was more than non-adjuvanted young reducing hospitalization due elderly. Other now different stages development some being tested clinical trials. perspective remains improve way prepared accelerate availability, case pandemics, enhance efficacy/effectiveness for a successful public health level.