Tyrosyl-DNA Phosphodiesterase I Inhibitors from the Australian Plant Macropteranthes leichhardtii
作者： Li-Wen Tian , Yunjiang Feng , Trong D. Tran , Yoko Shimizu , Tom Pfeifer
DOI: 10.1021/ACS.JNATPROD.5B00211
关键词:
摘要: Mass-directed isolation of the CH2Cl2/MeOH extract from bark an Australian plant, Macropteranthes leichhardtii, resulted in purification a new phenylpropanoid glucoside, macropteranthol (1), together with four known analogues (2–5). The structure compound 1 was elucidated by NMR and MS data analyses quantum chemical calculations. Compounds 3 5 showed inhibitory activity against tyrosyl-DNA phosphodiesterase I IC50 values ∼1.0 μM.
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