The genetics of depression and manic-depressive disorder.

摘要: Depressive disorders are more common in the relatives of depressed probands than population at large, and there is compelling evidence that familial aggregation bipolar disorder severe unipolar depression least partly due to genetic factors. However, concerning 'non-endogenous' less clear, family environment probably plays a stronger role. Much current research focused on two areas: firstly, mode inheritance manic-depressive illness, with use molecular biological techniques detect localise major genes; secondly, ways which predisposition environmental insults combine produce depressive disorder.