Sorafenib Therapy for Pediatric Acute Myeloid Leukemia with FMS-like Tyrosine Kinase 3-internal Tandem Duplication Mutations: 2 Case Reports
作者： Shinya Osone , Toshihiko Imamura , Takuyo Kanayama , Yusuke Tsuma , Sachiko Kawashima-Goto
DOI: 10.1097/MPH.0000000000000672
关键词:
摘要: Sorafenib is a promising agent for treating pediatric refractory acute myeloid leukemia (AML) exhibiting FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD); however, its optimal use needs to be established. We report 2 cases of FLT3-ITD-positive AML treated with sorafenib. Case 1 underwent stem cell transplantation (SCT) without entering remission, despite the chemotherapy. This patient relapsed receiving post-SCT Chemotherapy combined sorafenib successfully achieved complete remission in case 2. received and remains remission. The combination pre-SCT may thus effective AML.
sci-hub.se 参考文章(14)
Michael R. Grunwald, Mark J. Levis, FLT3 inhibitors for acute myeloid leukemia: a review of their efficacy and mechanisms of resistance International Journal of Hematology. ,vol. 97, pp. 683- 694 ,(2013) , 10.1007/S12185-013-1334-8
Katherine Tarlock, Bill Chang, Todd Cooper, Thomas Gross, Sumit Gupta, Steven Neudorf, Kathleen Adlard, Phoenix A. Ho, Suzanne McGoldrick, Tanya Watt, Tina Templeman, India Sisler, Amy Garee, Blythe Thomson, Ann Woolfrey, Elihu Estey, Soheil Meshinchi, Jessica A. Pollard, Sorafenib treatment following hematopoietic stem cell transplant in pediatric FLT3/ITD acute myeloid leukemia Pediatric Blood & Cancer. ,vol. 62, pp. 1048- 1054 ,(2015) , 10.1002/PBC.25437
Hisayuki Yokoyama, Andreas Lundqvist, Su Su, Richard Childs, Toxic effects of sorafenib when given early after allogeneic hematopoietic stem cell transplantation Blood. ,vol. 116, pp. 2858- 2859 ,(2010) , 10.1182/BLOOD-2010-06-291104
K W Pratz, E Cho, M J Levis, J E Karp, S D Gore, M McDevitt, A Stine, M Zhao, S D Baker, M A Carducci, J J Wright, M A Rudek, B D Smith, A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias Leukemia. ,vol. 24, pp. 1437- 1444 ,(2010) , 10.1038/LEU.2010.132
D Tomizawa, A Tawa, T Watanabe, A M Saito, K Kudo, T Taga, S Iwamoto, A Shimada, K Terui, H Moritake, A Kinoshita, H Takahashi, H Nakayama, K Koh, H Kigasawa, Y Kosaka, H Miyachi, K Horibe, T Nakahata, S Adachi, Excess treatment reduction including anthracyclines results in higher incidence of relapse in core binding factor acute myeloid leukemia in children Leukemia. ,vol. 27, pp. 2413- 2416 ,(2013) , 10.1038/LEU.2013.153
Mitsuru Miyachi, Eri Watanabe, Nobukazu Watanabe, Yusuke Tsuma, Sachiko Kawashima-Goto, Shinichi Tamura, Toshihiko Imamura, Hiroyuki Ishida, Hajime Hosoi, MRD detection of leukemia relapse using HLA typing by FACS in combination with FISH after mismatched allogeneic stem cell transplantation Pediatric Transplantation. ,vol. 18, ,(2014) , 10.1111/PETR.12267
Mark Levis, Rosalyn Pham, B. Douglas Smith, Donald Small, In vitro studies of a FLT3 inhibitor combined with chemotherapy: sequence of administration is important to achieve synergistic cytotoxic effects Blood. ,vol. 104, pp. 1145- 1150 ,(2004) , 10.1182/BLOOD-2004-01-0388
Yi-Bin Chen, Shuli Li, Andrew A. Lane, Christine Connolly, Candice Del Rio, Betsy Valles, Morgan Curtis, Karen Ballen, Corey Cutler, Bimalangshu R. Dey, Areej El-Jawahri, Amir T. Fathi, Vincent T. Ho, Amy Joyce, Steven McAfee, Michelle Rudek, Trivikram Rajkhowa, Sigitas Verselis, Joseph H. Antin, Thomas R. Spitzer, Mark Levis, Robert Soiffer, Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for fms-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia. Biology of Blood and Marrow Transplantation. ,vol. 20, pp. 2042- 2048 ,(2014) , 10.1016/J.BBMT.2014.09.007
Hiroto Inaba, Jeffrey E. Rubnitz, Elaine Coustan-Smith, Lie Li, Brian D. Furmanski, Gerard P. Mascara, Kenneth M. Heym, Robbin Christensen, Mihaela Onciu, Sheila A. Shurtleff, Stanley B. Pounds, Ching-Hon Pui, Raul C. Ribeiro, Dario Campana, Sharyn D. Baker, Phase I Pharmacokinetic and Pharmacodynamic Study of the Multikinase Inhibitor Sorafenib in Combination With Clofarabine and Cytarabine in Pediatric Relapsed/Refractory Leukemia Journal of Clinical Oncology. ,vol. 29, pp. 3293- 3300 ,(2011) , 10.1200/JCO.2011.34.7427
Shuiying Hu, Hongmei Niu, Hiroto Inaba, Shelley Orwick, Charles Rose, John C. Panetta, Shengping Yang, Stanley Pounds, Yiping Fan, Christopher Calabrese, Jerold E. Rehg, Dario Campana, Jeffrey E. Rubnitz, Sharyn D. Baker, Activity of the Multikinase Inhibitor Sorafenib in Combination With Cytarabine in Acute Myeloid Leukemia Journal of the National Cancer Institute. ,vol. 103, pp. 893- 905 ,(2011) , 10.1093/JNCI/DJR107