Effects of intraoperative colloid administration on outcome in a population-based general surgical cohort: a propensity score analysis.

摘要: BACKGROUND Many studies on colloids have recently been retracted, leaving us with uncertain evidence of their safety. We aimed to analyze whether intraoperative colloid administration is associated postoperative complications. METHODS The prospectively compiled database the ARISCAT study a large, representative cohort general surgical patients was reanalyzed compare outcomes according were administered or not; propensity score used adjust for potential confounders. primary major Secondary hospital-free days within 90 and mortality at 30 days. In retrospective survey we asked each center's data collectors estimate proportions different during period. RESULTS Of 2462 analyzed, 556 (22.6%) received some type intraoperatively. median (25th-75th percentile) total fluids significantly higher in receiving (10.0 [6.9-14.1] mL·kg-1·h-1 vs. 8.8 [6.0-12.8] not colloids; P<0.01). volume 7.5 (6.3-10.4) mL·kg-1. An estimated 75.7% third-generation hydroxyethyl starches (130/0.4). Significantly complications, after adjustment, atelectasis, respiratory infection, bronchospasm, arrhythmia, sepsis, paralytic ileum, hyperglycemia. Patients had 1.9 fewer (P<0.006). There no significant differences 30- 90-day mortality. CONCLUSION Our suggests an association administration, mainly 130/0.4 starches, diverse complications longer hospital stay. Controlled are urgently needed assess safety profile use patients.