The beta2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon.

摘要: The human Burkitt lymphoma cell line Daudi does not synthesize beta2-microglobulin (beta2m) and lacks the surface histocompatibility antigens. cells, however, contain RNA hybridizing to a cloned beta2m cDNA probe. from this RNA, was sequenced. By comparison with prepared Ramos which synthesized microglobulin, we determined sequence of 20 amino acid long leader peptide pre-beta2m show that in cells initiator ATG has been mutated ATC. Although cannot be translated, interferon induces as well normal cells.