Combinatorial design of biomaterials for drug delivery: opportunities and challenges.
作者： Latrisha K Petersen , Balaji Narasimhan
关键词:
摘要: Background: The rational design of biodegradable polymeric devices for controlled drug delivery and tissue engineering is an important area research advancing new therapies cancer, diabetes immune-related disorders. In era escalating costs discovery-based research, there urgent need to develop rapid methods systems. Objective/methods: By merging this field study with high throughput design, optimization development, researchers have been able accelerate the discovery processes these devices. Combinatorial enables identification key regions interest. Conclusion: This review focuses on opportunities challenges in combinatorial biomaterials delivery, as has a great deal significant progress over past decade propel approach biomaterials.
informapharmascience.com参考文章(55)
Stanislav Miertus, Giorgio Fassina, Combinatorial technologies in biotechnology Chimica Oggi-chemistry Today. ,vol. 21, pp. 28- 31 ,(2003)
Matt J. Kipper, Jennifer H. Wilson, Michael J. Wannemuehler, Balaji Narasimhan, Single dose vaccine based on biodegradable polyanhydride microspheres can modulate immune response mechanism. Journal of Biomedical Materials Research Part A. ,vol. 76, pp. 798- 810 ,(2006) , 10.1002/JBM.A.30545
Brandon M. Vogel, Joao T. Cabral, Naomi Eidelman, Balaji Narasimhan, Surya K. Mallapragada, Parallel Synthesis and High Throughput Dissolution Testing of Biodegradable Polyanhydride Copolymers ACS Combinatorial Science. ,vol. 7, pp. 921- 928 ,(2005) , 10.1021/CC050077P
Jon B. Thorstenson, Latrisha K. Petersen, Balaji Narasimhan, Combinatorial/high throughput methods for the determination of polyanhydride phase behavior ACS Combinatorial Science. ,vol. 11, pp. 820- 828 ,(2009) , 10.1021/CC900039K
Matt J. Kipper, Soenke Seifert, P. Thiyagarajan, Balaji Narasimhan, Understanding polyanhydride blend phase behavior using scattering, microscopy, and molecular simulations. Polymer. ,vol. 45, pp. 3329- 3340 ,(2004) , 10.1016/J.POLYMER.2004.03.052
Ying Mei, Tao Wu, Chang Xu, Kurt J. Langenbach, John T. Elliott, Bryan D. Vogt, Kathryn L. Beers, Eric J. Amis, Newell R. Washburn, Tuning Cell Adhesion on Gradient Poly(2-hydroxyethyl methacrylate)-Grafted Surfaces Langmuir. ,vol. 21, pp. 12309- 12314 ,(2005) , 10.1021/LA050668X
Edith Mathiowitz, Howard Bernstein, Steve Giannos, Phillip Dor, Tom Turek, Robert Langer, Polyanhydride microspheres. IV. Morphology and characterization of systems made by spray drying Journal of Applied Polymer Science. ,vol. 45, pp. 125- 134 ,(1992) , 10.1002/APP.1992.070450115
Carl G. Simon, Jean S. Stephens, Shauna M. Dorsey, Matthew L. Becker, Fabrication of combinatorial polymer scaffold libraries. Review of Scientific Instruments. ,vol. 78, pp. 072207- ,(2007) , 10.1063/1.2755761
A DETERMAN, J WILSON, M KIPPER, M WANNEMUEHLER, B NARASIMHAN, Protein stability in the presence of polymer degradation products: consequences for controlled release formulations. Biomaterials. ,vol. 27, pp. 3312- 3320 ,(2006) , 10.1016/J.BIOMATERIALS.2006.01.054
Brandon M. Vogel, Surya K. Mallapragada, Balaji Narasimhan, Rapid Synthesis of Polyanhydrides by Microwave Polymerization Macromolecular Rapid Communications. ,vol. 25, pp. 330- 333 ,(2004) , 10.1002/MARC.200300156