Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.

摘要: The liver enzymes alcohol dehydrogenase (ADH) and aldehyde (ALDH), which are responsible for the oxidative metabolism of ethanol, polymorphic in humans. An allele encoding an inactive form mitochondrial ALDH2 is known to reduce likelihood alcoholism Japanese. We hypothesized that polymorphisms both ALDH ADH modify predisposition development alcoholism. Therefore, we determined genotypes ADH2, ADH3, loci alcoholic nonalcoholic Chinese men living Taiwan, using leukocyte DNA amplified by PCR allele-specific oligonucleotides. alcoholics had significantly lower frequencies ADH2*2, ADH3*1, ALDH2*2 alleles than did nonalcoholics, suggesting genetic variation ALDH, modulating rate ethanol acetaldehyde, influences drinking behavior risk developing