Intraindividual comparison of gadolinium- and iodine-enhanced 64-slice multidetector CT pulmonary angiography for the detection of pulmonary embolism in a porcine model.

摘要: This study is an evaluation of the diagnostic accuracy gadolinium-enhanced computed tomography pulmonary angiography (CTPA) for detection embolism (PE) in comparison with iodine-enhanced CTPA. PE was induced five anesthetized pigs by administration blood clots through 11-F catheter inside jugular vein. Animals underwent CTPA breathhold i.v. bolus injection 50 ml gadopentetate dimeglumine (0.4 mmol/kg, 4 ml/s). Subsequently, performed using same imaging parameters but under 70 ml nonionic iodinated contrast material (400 mg/ml, All images were reconstructed 1 mm slice thickness. A consensus readout iodium-enhanced CTPAs both radiologists served as reference standard. Gadolinium-enhanced evaluated independently two experienced radiologists, and differences rate between agents assessed on a per embolus basis Wilcoxon signed-rank test. Interobserver agreement determined calculation қ values. diagnosed readers all use Out 60 emboli detected scans, 47 (78.3%; reader 1) 44 (62.8%; 2) gadolinium. 13 (100%) lobar arteries (by readers) 26 (reader 25 out 27 (96.3% 92.6%) segmental In subsegmental arteries, only 8 (40%; 6 (30%; 20 By comparing scans vessel (Wilcoxon test), Gd-enhanced significantly inferior level (P < 0.0001). The interobserver excellent (қ = 1.0 0.93, respectively), whereas reached moderate (қ = 0.56). Compared to conventional media, gadolinium-based achieve equivalent down level. may be considered alternative workup acute patients contraindications agents.