Next generation sequencing-based gene panel tests for the management of solid tumors.

摘要: Next generation sequencing (NGS) has been an invaluable tool to put genomic into clinical practice. The incorporation of clinically relevant target sequences NGS-based gene panel tests generated practical diagnostic tools that enable individualized cancer-patient care. utility testing includes investigation the genetic basis for individual's response therapy, such as signaling pathways associated with a specific therapies, microsatellite instability and hypermutated phenotype, deficiency in DNA double-strand break repair pathway. In this review, we describe concept precision cancer medicine using well importance control sample quality routine testing. We geographic ethnic differences genomes, discuss issues need be addressed future based on our experiences Japan.