Perivascular Inflammation After Balloon Angioplasty of Porcine Coronary Arteries
作者： Ei-ichi Okamoto , Tracey Couse , Hector De Leon , Jakob Vinten-Johansen , Richard B. Goodman
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摘要: Background Inflammation has been suggested to play a role in vascular lesion formation after angioplasty. Whereas previous studies have focused on inflammatory reactions the intima and media, less attention paid adventitial perivascular responses their potential remodeling. Methods Results Balloon overstretch injury of porcine coronary arteries was performed with standard clinical angioplasty catheters. Vessels were examined from 0.5 hour 14 days by immunohistochemistry situ hybridization (ISH) for neutrophil macrophage markers, cell adhesion molecules (P-selectin, E-selectin, molecule-1), neutrophil-specific CXC chemokines (alveolar macrophage–derived chemotactic factor [AMCF]-I/interleukin-8 AMCF-II). Neutrophils accumulated adventitia surrounding site 2 hours 3 days, followed macrophages 1 7 associated temporal...
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