Nanotopographical polymeric surface with mussel-inspired decoration to enhance osteoblast differentiation
作者： Hua-Mo Yin , Chaoying Mao , Wei Liu , Ya-Hui Liu , Yue Ren
DOI: 10.1016/J.APSUSC.2019.03.193
关键词:
摘要: Abstract Simultaneous existence of topographic and chemical cues on the polymeric surface was demonstrated to be a valid route accelerate osteoblast differentiation. Herein, nanotopographical pattern bioactive components were sequentially introduced onto poly( l -lactic acid) (PLLA) via etching treatment followed by mussel-inspired polydopamine (PDA) coating. The PLLA nanolamellae formed with roughness 62.0 nm extracting amorphous phase annealed PLLA. Subsequently, uniform PDA decoration obtained etched without changing dopamine self-polymerization. In vitro cell culture revealed that combination showed more significant promotion viability, alkaline phosphatase activity, osteopontin, collagen type I expression than only using or decoration. enhanced differentiation mediated integrin β1 signaling pathway. Our proposed approach opens simple, universal, promising gateway construct comprehensive for enhancing osteogenic
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