Sulfidation of silver nanoparticle reduces its toxicity in zebrafish

摘要: Chemical transformations of metal nanoparticles can be an important way to mitigate nanoparticle toxicity. Sulfidation silver (AgNPs) is a natural process shown occur in environment. Very few studies, employing microbes and embryonic stages zebrafish, have reduction AgNPs toxicity as direct result sulfidation. However the feasibility reducing by sulfidation has never been studied adult vertebrates. In this study, we used zebrafish model study efficacy battery biomarkers liver brain. While enhanced oxidative stress, altered detoxification enzymes affected brain acetylcholinesterase activity, resulted significant alleviation changes these parameters. Histopathological analyses sulphydryl levels also support significance sulfidated controlling AgNPs. Our provides first biochemical data on importance biological