Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume

摘要: Water deprivation and hypernatremia are major challenges for water sodium homeostasis. Cellular integrity requires maintenance of concentration within narrow limits. This regulation is obtained through engagement multiple mechanisms neural pathways that regulate the volume composition extracellular fluid. The purpose this short review to summarize literature on central underlying cardiovascular, hormonal autonomic responses circulating changes, some findings in last 12 years by our laboratory. We data start with afferents carotid body project medullary relays nucleus tractus solitarii caudal ventrolateral medulla, which turn median preoptic forebrain. also suggesting noradrenergic A1 cells medulla represent an essential link controlling fluid renal excretion. Finally, recent from laboratory suggest these structures may be involved beneficial effects intravenous infusion hypertonic saline recovery hemorrhagic shock.